Assay Detail
Binding
CHEMBL828756
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Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptor
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.17 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 8.32 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.00 |
| CHEMBL435301 | — | — | 1 | 8.00 |
| CHEMBL654 | MIRTAZAPINE | 4.0 | 1 | 7.70 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.62 |
| CHEMBL193639 | — | — | 2 | 7.18 |
| CHEMBL363581 | — | — | 1 | 7.14 |
| CHEMBL329566 | — | — | 1 | 6.90 |
| CHEMBL366164 | — | — | 1 | 6.81 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 6.72 |
| CHEMBL195706 | — | — | 1 | 6.60 |
| CHEMBL194659 | — | — | 1 | 6.57 |
| CHEMBL364270 | — | — | 1 | 6.52 |
| CHEMBL193435 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6437 | MIANSERIN | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL85 | RISPERIDONE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL435301 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL654 | MIRTAZAPINE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL42 | CLOZAPINE | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL193639 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL363581 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL193639 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL329566 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL366164 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL715 | OLANZAPINE | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL195706 | — | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL194659 | — | Ki | = | 269.0 | nM | 6.57 |
| CHEMBL364270 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL193435 | — | Ki | = | 407.0 | nM | 6.39 |