Assay Detail
Binding
CHEMBL828777
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Inhibitory activity against Carbonic anhydrase II
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 7.46 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 8.52 |
| CHEMBL369179 | — | — | 1 | 8.29 |
| CHEMBL369045 | — | — | 1 | 8.14 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.05 |
| CHEMBL367844 | — | — | 1 | 8.05 |
| CHEMBL179047 | — | — | 1 | 8.04 |
| CHEMBL180111 | — | — | 1 | 8.02 |
| CHEMBL175866 | — | — | 1 | 8.01 |
| CHEMBL367378 | — | — | 1 | 7.96 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL179136 | — | — | 1 | 7.89 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL178948 | — | — | 1 | 7.82 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.82 |
| CHEMBL368235 | — | — | 1 | 7.82 |
| CHEMBL176283 | — | — | 1 | 7.75 |
| CHEMBL179021 | — | — | 1 | 7.60 |
| CHEMBL175881 | — | — | 1 | 7.48 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL176180 | — | — | 1 | 7.29 |
| CHEMBL175486 | — | — | 1 | 7.27 |
| CHEMBL359546 | — | — | 1 | 7.17 |
| CHEMBL176203 | — | — | 1 | 7.12 |
| CHEMBL176495 | — | — | 1 | 7.11 |
| CHEMBL7204 | — | — | 1 | 7.08 |
| CHEMBL175503 | — | — | 1 | 7.07 |
| CHEMBL179682 | — | — | 1 | 7.04 |
| CHEMBL180012 | — | — | 1 | 7.03 |
| CHEMBL175432 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL369179 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL369045 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL367844 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL179047 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL180111 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL175866 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL367378 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL179136 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL368235 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL77517 | INDISULAM | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL178948 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL176283 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL179021 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL175881 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL176180 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL175486 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL359546 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL176203 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL176495 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL7204 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL175503 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL179682 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL180012 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL175432 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL179137 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL180323 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL414 | CARZENIDE | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL175652 | — | Ki | = | 264.0 | nM | 6.58 |
| CHEMBL6705 | — | Ki | = | 295.0 | nM | 6.53 |
| CHEMBL361191 | — | Ki | = | 338.0 | nM | 6.47 |
| CHEMBL148680 | — | Ki | = | 420.0 | nM | 6.38 |