Assay Detail
Binding
CHEMBL828778
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Carbonic anhydrase IX
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 7.46 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL369179 | — | — | 1 | 8.49 |
| CHEMBL179047 | — | — | 1 | 8.27 |
| CHEMBL367378 | — | — | 1 | 8.27 |
| CHEMBL175866 | — | — | 1 | 8.24 |
| CHEMBL180111 | — | — | 1 | 8.21 |
| CHEMBL178948 | — | — | 1 | 8.15 |
| CHEMBL179136 | — | — | 1 | 8.10 |
| CHEMBL176283 | — | — | 1 | 8.10 |
| CHEMBL368235 | — | — | 1 | 8.08 |
| CHEMBL367844 | — | — | 1 | 8.07 |
| CHEMBL369045 | — | — | 1 | 8.07 |
| CHEMBL179021 | — | — | 1 | 7.89 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.62 |
| CHEMBL175881 | — | — | 1 | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.57 |
| CHEMBL175486 | — | — | 1 | 7.50 |
| CHEMBL6705 | — | — | 1 | 7.48 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.47 |
| CHEMBL359546 | — | — | 1 | 7.46 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 7.43 |
| CHEMBL176495 | — | — | 1 | 7.32 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.28 |
| CHEMBL175432 | — | — | 1 | 7.19 |
| CHEMBL175503 | — | — | 1 | 7.16 |
| CHEMBL180012 | — | — | 1 | 7.14 |
| CHEMBL179137 | — | — | 1 | 7.12 |
| CHEMBL179682 | — | — | 1 | 7.08 |
| CHEMBL176180 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL369179 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL179047 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL367378 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL175866 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL180111 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL178948 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL179136 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL176283 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL368235 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL369045 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL367844 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL179021 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL77517 | INDISULAM | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL175881 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL175486 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL6705 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL359546 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL176495 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL175432 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL175503 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL180012 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL179137 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL179682 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL176180 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL176203 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL180323 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL175652 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL7204 | — | Ki | = | 265.0 | nM | 6.58 |
| CHEMBL414 | CARZENIDE | Ki | = | 346.0 | nM | 6.46 |
| CHEMBL361191 | — | Ki | = | 547.0 | nM | 6.26 |
| CHEMBL148680 | — | Ki | = | 680.0 | nM | 6.17 |