Assay Detail
Binding
CHEMBL828790
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human melanin concentrating hormone receptor 1
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.88 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364162 | — | — | 1 | 8.80 |
| CHEMBL191393 | — | — | 1 | 8.74 |
| CHEMBL363044 | — | — | 1 | 8.72 |
| CHEMBL364871 | — | — | 1 | 8.59 |
| CHEMBL189147 | — | — | 1 | 8.48 |
| CHEMBL191409 | — | — | 1 | 8.40 |
| CHEMBL190780 | — | — | 1 | 8.25 |
| CHEMBL187721 | — | — | 1 | 8.24 |
| CHEMBL189611 | — | — | 1 | 8.22 |
| CHEMBL190401 | — | — | 1 | 8.22 |
| CHEMBL191078 | — | — | 1 | 8.15 |
| CHEMBL191079 | — | — | 1 | 8.15 |
| CHEMBL187931 | — | — | 1 | 8.14 |
| CHEMBL187996 | — | — | 1 | 8.09 |
| CHEMBL433596 | — | — | 1 | 8.05 |
| CHEMBL189029 | — | — | 1 | 7.96 |
| CHEMBL433591 | — | — | 1 | 7.90 |
| CHEMBL191390 | — | — | 1 | 7.72 |
| CHEMBL190219 | — | — | 1 | 7.70 |
| CHEMBL187719 | — | — | 1 | 7.01 |
| CHEMBL371809 | — | — | 1 | 6.86 |
| CHEMBL187942 | — | — | 1 | 6.78 |
| CHEMBL363459 | — | — | 1 | 6.71 |
| CHEMBL188088 | — | — | 1 | 6.63 |
| CHEMBL186156 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364162 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL191393 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL363044 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL364871 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL189147 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL191409 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL190780 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL187721 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL189611 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL190401 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL191078 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL191079 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL187931 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL187996 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL433596 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL189029 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL433591 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL191390 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL190219 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL187719 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL371809 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL187942 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL363459 | — | Ki | = | 197.0 | nM | 6.71 |
| CHEMBL188088 | — | Ki | = | 233.0 | nM | 6.63 |
| CHEMBL186156 | — | Ki | = | 374.0 | nM | 6.43 |