Assay Detail
Binding
CHEMBL828797
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Binding affinity for H1 histamine receptor expressed in CHO cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Norpiperidine imidazoazepines as a new class of potent, selective, and nonsedative H1 antihistamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.61 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444353 | — | — | 1 | 7.92 |
| CHEMBL539843 | VAPITADINE DIHYDROCHLORIDE | 2.0 | 1 | 7.72 |
| CHEMBL360953 | — | — | 1 | 7.66 |
| CHEMBL998 | LORATADINE | 4.0 | 1 | 7.43 |
| CHEMBL1201190 | LEVOCETIRIZINE DIHYDROCHLORIDE | 4.0 | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444353 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL539843 | VAPITADINE DIHYDROCHLORIDE | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL360953 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL998 | LORATADINE | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL1201190 | LEVOCETIRIZINE DIHYDROCHLORIDE | Ki | = | 50.0 | nM | 7.30 |