Assay Detail
Binding
CHEMBL828801
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DPCPX binding to adenosine A1 receptors of bovine cortical membranes
21
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 6.63 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL251997 | — | — | 1 | 8.52 |
| CHEMBL400189 | — | — | 1 | 8.00 |
| CHEMBL119709 | IB-MECA | — | 1 | 7.92 |
| CHEMBL464859 | NECA | — | 1 | 7.85 |
| CHEMBL66393 | — | — | 1 | 7.64 |
| CHEMBL2113609 | — | — | 1 | 7.52 |
| CHEMBL444550 | — | — | 2 | 7.30 |
| CHEMBL2113608 | — | — | 1 | 6.49 |
| CHEMBL606495 | — | — | 1 | 6.46 |
| CHEMBL194031 | — | — | 1 | 6.46 |
| CHEMBL611115 | — | — | 1 | 6.46 |
| CHEMBL2113641 | — | — | 1 | 6.34 |
| CHEMBL2113418 | — | — | 1 | 6.11 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 6.05 |
| CHEMBL73809 | — | — | 1 | 5.95 |
| CHEMBL2113640 | — | — | 1 | 5.88 |
| CHEMBL2113642 | — | — | 1 | 5.37 |
| CHEMBL2113607 | — | — | 1 | 5.34 |
| CHEMBL481858 | — | — | 1 | 5.27 |
| CHEMBL2113643 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL251997 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL400189 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL119709 | IB-MECA | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL464859 | NECA | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL66393 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL2113609 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL444550 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL444550 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL2113608 | — | Ki | = | 325.0 | nM | 6.49 |
| CHEMBL194031 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL606495 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL611115 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL2113641 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL2113418 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL73809 | — | Ki | = | 1120.0 | nM | 5.95 |
| CHEMBL2113640 | — | Ki | = | 1310.0 | nM | 5.88 |
| CHEMBL2113642 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL2113607 | — | Ki | = | 4530.0 | nM | 5.34 |
| CHEMBL481858 | — | Ki | = | 5370.0 | nM | 5.27 |
| CHEMBL2113643 | — | Ki | = | 5620.0 | nM | 5.25 |