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Assay Detail

CHEMBL828804

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]CP-55940 binding to cannabinoid receptor 1 of rat brain
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Cannabinoid receptor 1 (CHEMBL3571)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Adamantyl cannabinoids: a novel class of cannabinergic ligands.
Lu D, Meng Z, Thakur GA, Fan P, Steed J, Tartal CL, Hurst DP, Reggio PH, Deschamps JR, Parrish DA, George C, Järbe TU, Lamb RJ, Makriyannis A.
J Med Chem (2005) 48 : 4576 -4585
PubMed 15999995 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 6 7.48 8.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL434351 1 8.17
CHEMBL480107 1 7.53
CHEMBL371167 1 7.46
CHEMBL267227 DELTA-8-TETRAHYDROCANNABINOL 2.0 1 7.32
CHEMBL191324 1 7.31
CHEMBL372866 1 7.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL434351 Ki = 6.8 nM 8.17
CHEMBL480107 Ki = 29.3 nM 7.53
CHEMBL371167 Ki = 34.9 nM 7.46
CHEMBL267227 DELTA-8-TETRAHYDROCANNABINOL Ki = 47.6 nM 7.32
CHEMBL191324 Ki = 48.6 nM 7.31
CHEMBL372866 Ki = 79.7 nM 7.10