Assay Detail
Binding
CHEMBL828815
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Ki value against human carbonic anhydrase XII (hCA XII)
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 8.05 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 9.52 |
| CHEMBL6705 | — | — | 1 | 9.07 |
| CHEMBL6853 | — | — | 1 | 8.96 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | 3.0 | 1 | 8.74 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 8.52 |
| CHEMBL7092 | — | — | 1 | 8.51 |
| CHEMBL7087 | — | — | 1 | 8.49 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 8.47 |
| CHEMBL182723 | — | — | 1 | 8.47 |
| CHEMBL6633 | — | — | 1 | 8.47 |
| CHEMBL266026 | — | — | 1 | 8.46 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.46 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 8.46 |
| CHEMBL6685 | — | — | 1 | 8.43 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 8.41 |
| CHEMBL6753 | — | — | 1 | 8.40 |
| CHEMBL7146 | — | — | 1 | 8.35 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL268177 | — | — | 1 | 7.96 |
| CHEMBL183913 | — | — | 1 | 7.96 |
| CHEMBL6724 | — | — | 1 | 7.70 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.66 |
| CHEMBL265674 | — | — | 1 | 7.48 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 7.47 |
| CHEMBL360356 | — | — | 1 | 7.44 |
| CHEMBL174847 | — | — | 1 | 7.43 |
| CHEMBL266240 | — | — | 1 | 7.36 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 7.35 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL6784 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419 | MAFENIDE | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL6705 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL6853 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL7092 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL7087 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL182723 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL6633 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL266026 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL6685 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL26 | SULPIRIDE | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL6753 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL7146 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL268177 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL183913 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL6724 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL265674 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL414 | CARZENIDE | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL360356 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL174847 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL266240 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL6784 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL176495 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL268439 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL6919 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 3.8 | nM | - |