Assay Detail
Binding
CHEMBL828849
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 of rat cortical membranes
9
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907596) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Corrigendum to Epibatidine structureactivity relationships
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 9.89 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 2 | 10.70 |
| CHEMBL186302 | — | — | 1 | 10.40 |
| CHEMBL186070 | — | — | 1 | 10.30 |
| CHEMBL426974 | — | — | 3 | 9.89 |
| CHEMBL185667 | — | — | 1 | - |
| CHEMBL363973 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL186302 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL186070 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL426974 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL6623 | EPIBATIDINE | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL426974 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL426974 | — | Ki | = | 1.25 | nM | 8.90 |
| CHEMBL185667 | — | Ki | > | 38.0 | nM | - |
| CHEMBL363973 | — | Ki | > | 38.0 | nM | - |