Assay Detail
Binding
CHEMBL828851
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]cytisine binding to Nicotinic acetylcholine receptor alpha4-beta2 of rat cortical membranes
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907596) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Corrigendum to Epibatidine structureactivity relationships
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 9.17 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186302 | — | — | 1 | 10.52 |
| CHEMBL6623 | EPIBATIDINE | — | 2 | 10.40 |
| CHEMBL361298 | — | — | 1 | 9.33 |
| CHEMBL185667 | — | — | 1 | 8.18 |
| CHEMBL363973 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186302 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL6623 | EPIBATIDINE | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL361298 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL6623 | EPIBATIDINE | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL185667 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL363973 | — | Ki | = | 30.0 | nM | 7.52 |