Assay Detail
Binding
CHEMBL828868
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125 I]-alpha Bungarotoxin binding to alpha 7 nicotinic acetylcholine receptor of rat cortex membranes
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and alpha4beta2 nicotinic affinity of 2-pyrrolidinylmethoxyimines and prolinal oxime ethers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.23 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3 | NICOTINE | 4.0 | 1 | 6.34 |
| CHEMBL274525 | ABT-418 | — | 1 | 5.92 |
| CHEMBL362727 | — | — | 1 | 4.33 |
| CHEMBL186295 | — | — | 1 | 4.31 |
| CHEMBL2096795 | — | — | 1 | - |
| CHEMBL185124 | — | — | 1 | - |
| CHEMBL361293 | — | — | 1 | - |
| CHEMBL187861 | — | — | 1 | - |
| CHEMBL364986 | — | — | 1 | - |
| CHEMBL412407 | — | — | 1 | - |
| CHEMBL185926 | — | — | 1 | - |
| CHEMBL365474 | — | — | 1 | - |
| CHEMBL187098 | — | — | 1 | - |
| CHEMBL2096794 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3 | NICOTINE | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL274525 | ABT-418 | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL362727 | — | Ki | = | 47000.0 | nM | 4.33 |
| CHEMBL186295 | — | Ki | = | 49000.0 | nM | 4.31 |
| CHEMBL2096795 | — | Ki | - | nM | - | |
| CHEMBL185124 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL361293 | — | Ki | - | nM | - | |
| CHEMBL187861 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL364986 | — | Ki | - | nM | - | |
| CHEMBL412407 | — | Ki | - | nM | - | |
| CHEMBL185926 | — | Ki | - | nM | - | |
| CHEMBL365474 | — | Ki | - | nM | - | |
| CHEMBL187098 | — | Ki | - | nM | - | |
| CHEMBL2096794 | — | Ki | > | 50000.0 | nM | - |