Assay Detail
Binding
CHEMBL828870
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Displacement of [125I]AB-MECA from adenosine A3 receptors in bovine cortical membranes
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.57 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 9.66 |
| CHEMBL119709 | IB-MECA | — | 1 | 8.06 |
| CHEMBL66393 | — | — | 1 | 7.82 |
| CHEMBL444550 | — | — | 2 | 7.19 |
| CHEMBL464859 | NECA | — | 1 | 7.14 |
| CHEMBL400189 | — | — | 1 | 6.66 |
| CHEMBL194031 | — | — | 1 | 6.62 |
| CHEMBL2113418 | — | — | 1 | 6.38 |
| CHEMBL2113608 | — | — | 1 | 6.32 |
| CHEMBL2113641 | — | — | 1 | 6.17 |
| CHEMBL2113640 | — | — | 1 | 5.92 |
| CHEMBL2113609 | — | — | 1 | 5.59 |
| CHEMBL2113642 | — | — | 1 | 5.57 |
| CHEMBL2113643 | — | — | 1 | 5.46 |
| CHEMBL2113607 | — | — | 1 | 5.24 |
| CHEMBL251997 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431733 | NAMODENOSON | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL119709 | IB-MECA | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL66393 | — | Ki | = | 15.2 | nM | 7.82 |
| CHEMBL444550 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL464859 | NECA | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL444550 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL400189 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL194031 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL2113418 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL2113608 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL2113641 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL2113640 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL2113609 | — | Ki | = | 2560.0 | nM | 5.59 |
| CHEMBL2113642 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL2113643 | — | Ki | = | 3510.0 | nM | 5.46 |
| CHEMBL2113607 | — | Ki | = | 5780.0 | nM | 5.24 |
| CHEMBL251997 | — | Ki | = | 8570.0 | nM | 5.07 |