Assay Detail
Binding
CHEMBL828874
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards dopamine D3 receptor in ventral striatal membranes of sprague-dawley rat brain by using [3H]-PD 128907 as radioligand
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and evaluation of hexahydrobenz[f]isoquinolines as a novel class of dopamine 3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.48 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25236 | BP-897 | — | 1 | 8.96 |
| CHEMBL188584 | — | — | 1 | 8.21 |
| CHEMBL188713 | — | — | 1 | 7.60 |
| CHEMBL186035 | — | — | 1 | 7.42 |
| CHEMBL185841 | — | — | 1 | 7.20 |
| CHEMBL187190 | — | — | 1 | 7.13 |
| CHEMBL186350 | — | — | 1 | 7.08 |
| CHEMBL185743 | — | — | 1 | 6.99 |
| CHEMBL361299 | — | — | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25236 | BP-897 | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL188584 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL188713 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL186035 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL185841 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL187190 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL186350 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL185743 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL361299 | — | Ki | = | 183.0 | nM | 6.74 |