Assay Detail
Binding
CHEMBL828877
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Ability to inhibit the binding of [3H]PGD-2 radioligand to membranes of CHO cells stably expressing human Prostaglandin D2 receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of orally active prostaglandin D2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.39 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364841 | — | — | 1 | 8.46 |
| CHEMBL185251 | — | — | 1 | 8.28 |
| CHEMBL364593 | — | — | 1 | 8.00 |
| CHEMBL363984 | — | — | 1 | 7.70 |
| CHEMBL184684 | — | — | 1 | 7.52 |
| CHEMBL365829 | — | — | 1 | 7.30 |
| CHEMBL365908 | — | — | 1 | 6.89 |
| CHEMBL365696 | — | — | 1 | 6.77 |
| CHEMBL186735 | — | — | 1 | 6.54 |
| CHEMBL359564 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364841 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL185251 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL364593 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL363984 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL184684 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL365829 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL365908 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL365696 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL186735 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL359564 | — | Ki | = | 390.0 | nM | 6.41 |