Assay Detail
Binding
CHEMBL828903
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Inhibitory constant against human Carbonic anhydrase II
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 45 | 7.31 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 8.52 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.05 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL191380 | — | — | 1 | 7.85 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.82 |
| CHEMBL363874 | — | — | 1 | 7.80 |
| CHEMBL190550 | — | — | 1 | 7.75 |
| CHEMBL364754 | — | — | 1 | 7.68 |
| CHEMBL364919 | — | — | 1 | 7.64 |
| CHEMBL190721 | — | — | 1 | 7.57 |
| CHEMBL190024 | — | — | 1 | 7.55 |
| CHEMBL191045 | — | — | 1 | 7.54 |
| CHEMBL371403 | — | — | 1 | 7.51 |
| CHEMBL189526 | — | — | 1 | 7.50 |
| CHEMBL190907 | — | — | 1 | 7.48 |
| CHEMBL190733 | — | — | 1 | 7.48 |
| CHEMBL192834 | — | — | 1 | 7.48 |
| CHEMBL189523 | — | — | 1 | 7.46 |
| CHEMBL189681 | — | — | 1 | 7.44 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL366223 | — | — | 1 | 7.42 |
| CHEMBL190023 | — | — | 1 | 7.41 |
| CHEMBL190538 | — | — | 1 | 7.41 |
| CHEMBL191884 | — | — | 1 | 7.34 |
| CHEMBL193513 | — | — | 1 | 7.31 |
| CHEMBL189527 | — | — | 1 | 7.30 |
| CHEMBL193178 | — | — | 1 | 7.21 |
| CHEMBL434909 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL191380 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL77517 | INDISULAM | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL363874 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL190550 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL364754 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL364919 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL190721 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL190024 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL191045 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL371403 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL189526 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL190907 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL190733 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL192834 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL189523 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL189681 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL366223 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL190023 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL190538 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL191884 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL193513 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL189527 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL193178 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL434909 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL191576 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL440026 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL192950 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL190464 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL366276 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL372442 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL190531 | — | Ki | = | 146.0 | nM | 6.84 |
| CHEMBL190056 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL371632 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL190278 | — | Ki | = | 216.0 | nM | 6.67 |
| CHEMBL190329 | — | Ki | = | 326.0 | nM | 6.49 |
| CHEMBL426625 | — | Ki | = | 338.0 | nM | 6.47 |
| CHEMBL365380 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL192670 | — | Ki | = | 596.0 | nM | 6.22 |
| CHEMBL193008 | — | Ki | = | 765.0 | nM | 6.12 |