Assay Detail
Binding
CHEMBL828904
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Inhibitory constant against human Carbonic anhydrase II
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.09 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL167179 | — | — | 1 | 8.15 |
| CHEMBL166340 | — | — | 1 | 7.80 |
| CHEMBL169486 | — | — | 1 | 7.50 |
| CHEMBL168910 | — | — | 1 | 7.44 |
| CHEMBL370104 | — | — | 1 | 7.30 |
| CHEMBL67749 | — | — | 1 | 7.20 |
| CHEMBL195370 | — | — | 1 | 7.05 |
| CHEMBL68536 | PERFLUOROPHENYL SULFAMATE | — | 1 | 6.95 |
| CHEMBL303601 | — | — | 1 | 6.86 |
| CHEMBL24119 | — | — | 1 | 6.83 |
| CHEMBL193396 | — | — | 1 | 6.50 |
| CHEMBL193635 | — | — | 1 | 6.33 |
| CHEMBL195540 | — | — | 1 | 6.25 |
| CHEMBL355001 | SULFAMIDE | — | 1 | - |
| CHEMBL305268 | METHANESULFONAMIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL167179 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL166340 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL169486 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL168910 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL370104 | — | Ki | = | 50.5 | nM | 7.30 |
| CHEMBL67749 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL195370 | — | Ki | = | 89.6 | nM | 7.05 |
| CHEMBL68536 | PERFLUOROPHENYL SULFAMATE | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL303601 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL24119 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL193396 | — | Ki | = | 313.0 | nM | 6.50 |
| CHEMBL193635 | — | Ki | = | 473.0 | nM | 6.33 |
| CHEMBL195540 | — | Ki | = | 566.0 | nM | 6.25 |
| CHEMBL355001 | SULFAMIDE | Ki | = | 1130000.0 | nM | - |
| CHEMBL305268 | METHANESULFONAMIDE | Ki | = | 390000.0 | nM | - |