Assay Detail
Binding
CHEMBL828905
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Inhibitory constant against human Carbonic anhydrase II
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.32 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL195509 | — | — | 1 | 8.14 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL364081 | — | — | 1 | 8.09 |
| CHEMBL196285 | — | — | 1 | 8.00 |
| CHEMBL195194 | — | — | 1 | 7.99 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL193964 | — | — | 1 | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.82 |
| CHEMBL7146 | — | — | 1 | 7.52 |
| CHEMBL266026 | — | — | 1 | 7.48 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL269122 | — | — | 1 | 7.34 |
| CHEMBL196198 | — | — | 1 | 7.34 |
| CHEMBL7087 | — | — | 1 | 6.80 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 6.77 |
| CHEMBL362989 | — | — | 1 | 6.75 |
| CHEMBL195811 | — | — | 1 | 6.66 |
| CHEMBL195978 | — | — | 1 | 6.56 |
| CHEMBL195147 | — | — | 1 | 6.54 |
| CHEMBL196435 | — | — | 1 | 6.54 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.52 |
| CHEMBL365344 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL195509 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL364081 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL196285 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL195194 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL193964 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL77517 | INDISULAM | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL7146 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL266026 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL269122 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL196198 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL7087 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL419 | MAFENIDE | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL362989 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL195811 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL195978 | — | Ki | = | 278.0 | nM | 6.56 |
| CHEMBL195147 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL196435 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL365344 | — | Ki | = | 640.0 | nM | 6.19 |