Assay Detail
Binding
CHEMBL828908
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Inhibitory constant against human Carbonic anhydrase IX
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.84 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196198 | — | — | 1 | 8.34 |
| CHEMBL195811 | — | — | 1 | 8.32 |
| CHEMBL195509 | — | — | 1 | 8.32 |
| CHEMBL365344 | — | — | 1 | 8.30 |
| CHEMBL195194 | — | — | 1 | 8.30 |
| CHEMBL196435 | — | — | 1 | 8.28 |
| CHEMBL193964 | — | — | 1 | 8.27 |
| CHEMBL362989 | — | — | 1 | 8.25 |
| CHEMBL196285 | — | — | 1 | 8.21 |
| CHEMBL195978 | — | — | 1 | 8.19 |
| CHEMBL195147 | — | — | 1 | 8.17 |
| CHEMBL364081 | — | — | 1 | 8.17 |
| CHEMBL7146 | — | — | 1 | 7.62 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.57 |
| CHEMBL266026 | — | — | 1 | 7.51 |
| CHEMBL7087 | — | — | 1 | 7.48 |
| CHEMBL269122 | — | — | 1 | 7.47 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.47 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 6.99 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196198 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL195811 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL195509 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL365344 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL195194 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL196435 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL193964 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL362989 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL196285 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL195978 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL195147 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL364081 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL7146 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL77517 | INDISULAM | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL266026 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL7087 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL269122 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL419 | MAFENIDE | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 294.0 | nM | 6.53 |