Assay Detail
Binding
CHEMBL828939
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Effective concentration of compound against heat shock protein HSP90 determined in normal heart cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | heart |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.47 | 4.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192647 | — | — | 1 | 4.74 |
| CHEMBL192062 | — | — | 1 | 4.72 |
| CHEMBL191635 | — | — | 1 | 4.57 |
| CHEMBL191786 | — | — | 1 | 4.57 |
| CHEMBL192145 | — | — | 1 | 4.53 |
| CHEMBL193282 | — | — | 1 | 4.28 |
| CHEMBL273986 | — | — | 1 | 4.18 |
| CHEMBL365159 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192647 | — | EC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL192062 | — | EC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL191635 | — | EC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL191786 | — | EC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL192145 | — | EC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL193282 | — | EC50 | = | 53100.0 | nM | 4.28 |
| CHEMBL273986 | — | EC50 | = | 66300.0 | nM | 4.18 |
| CHEMBL365159 | — | EC50 | = | 65300.0 | nM | 4.18 |