Assay Detail
Binding
CHEMBL828953
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory effect against Escherichia coli peptide deformylase (PDF) by DPPI assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Macrocyclic inhibitors for peptide deformylase: a structure-activity relationship study of the ring size.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.95 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431210 | — | — | 1 | 7.96 |
| CHEMBL360609 | — | — | 1 | 7.64 |
| CHEMBL188894 | — | — | 1 | 7.20 |
| CHEMBL365632 | — | — | 1 | 7.13 |
| CHEMBL365416 | — | — | 1 | 7.11 |
| CHEMBL188671 | — | — | 1 | 7.04 |
| CHEMBL364836 | — | — | 1 | 7.02 |
| CHEMBL441502 | — | — | 1 | 6.96 |
| CHEMBL364979 | — | — | 1 | 6.59 |
| CHEMBL361449 | — | — | 1 | 6.15 |
| CHEMBL365910 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431210 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL360609 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL188894 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL365632 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL365416 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL188671 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL364836 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL441502 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL364979 | — | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL361449 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL365910 | — | Ki | = | 2100.0 | nM | 5.68 |