Assay Detail
Binding
CHEMBL828964
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human melanocortin 1 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanocyte-stimulating hormone receptor (CHEMBL3795) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Piperazinebenzylamines as potent and selective antagonists of the human melanocortin-4 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.82 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186289 | — | — | 1 | 5.92 |
| CHEMBL186083 | — | — | 1 | 5.89 |
| CHEMBL186074 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186289 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL186083 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL186074 | — | Ki | = | 2300.0 | nM | 5.64 |