Assay Detail
Binding
CHEMBL828969
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha-1-beta-1-delta-gamma of electroplax
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | pisces |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.83 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497939 | CYTISINICLINE | 3.0 | 1 | 6.60 |
| CHEMBL191174 | — | — | 1 | 6.47 |
| CHEMBL365965 | — | — | 1 | 5.52 |
| CHEMBL373359 | — | — | 1 | 5.35 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497939 | CYTISINICLINE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL191174 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL365965 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL373359 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL3 | NICOTINE | Ki | = | 6300.0 | nM | 5.20 |