Assay Detail
Functional
CHEMBL829007
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration from [3H]thymidine uptake assay in CHO10001 cells expressing human Dopamine receptor D4.2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO10001 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Fancy bioisosteres: metallocene-derived G-protein-coupled receptor ligands with subnanomolar binding affinity and novel selectivity profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.06 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364516 | N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-1-ferra-1,1'-spirobi[pentacyclo[2.2.0.0^{1,3}.0^{1,5}.0^{2,6}]hexane]-2,2',4,4'-tetraene-6-carboxamide | — | 1 | 9.26 |
| CHEMBL191962 | N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-1-ruthena-1,1'-spirobi[pentacyclo[2.2.0.0^{1,3}.0^{1,5}.0^{2,6}]hexane]-2,2',4,4'-tetraene-6-carboxamide | — | 1 | 8.92 |
| CHEMBL194555 | Fe complex | — | 1 | 8.12 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 7.72 |
| CHEMBL195083 | N-{4-[4-(3-chloro-2-methoxyphenyl)piperazin-1-yl]butyl}-1-ferra-1,1'-spirobi[pentacyclo[2.2.0.0^{1,3}.0^{1,5}.0^{2,6}]hexane]-2,2',4,4'-tetraene-6-carboxamide | — | 1 | 7.66 |
| CHEMBL370297 | Ruthenium complex | — | 1 | 7.46 |
| CHEMBL540612 | — | — | 1 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364516 | N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-1-ferra-1,1'-spirobi[pentacyclo[2.2.0.0^{1,3}.0^{1,5}.0^{2,6}]hexane]-2,2',4,4'-tetraene-6-carboxamide | EC50 | = | 0.55 | nM | 9.26 |
| CHEMBL191962 | N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-1-ruthena-1,1'-spirobi[pentacyclo[2.2.0.0^{1,3}.0^{1,5}.0^{2,6}]hexane]-2,2',4,4'-tetraene-6-carboxamide | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL194555 | Fe complex | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL240773 | QUINPIROLE | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL195083 | N-{4-[4-(3-chloro-2-methoxyphenyl)piperazin-1-yl]butyl}-1-ferra-1,1'-spirobi[pentacyclo[2.2.0.0^{1,3}.0^{1,5}.0^{2,6}]hexane]-2,2',4,4'-tetraene-6-carboxamide | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL370297 | Ruthenium complex | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL540612 | — | EC50 | = | 49.0 | nM | 7.31 |