Assay Detail
Functional
CHEMBL829011
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity towards thyroid hormone receptor expressed in human HepG2 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel heterocyclic thyromimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 8.07 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182339 | — | — | 1 | 9.70 |
| CHEMBL361162 | — | — | 1 | 9.30 |
| CHEMBL360137 | — | — | 1 | 8.92 |
| CHEMBL183176 | — | — | 1 | 8.52 |
| CHEMBL183050 | — | — | 1 | 8.40 |
| CHEMBL359647 | — | — | 1 | 8.40 |
| CHEMBL183122 | — | — | 1 | 8.40 |
| CHEMBL183000 | — | — | 1 | 8.11 |
| CHEMBL183851 | — | — | 1 | 8.10 |
| CHEMBL182430 | — | — | 1 | 8.10 |
| CHEMBL183863 | — | — | 1 | 7.96 |
| CHEMBL183727 | — | — | 1 | 7.82 |
| CHEMBL183057 | — | — | 1 | 7.82 |
| CHEMBL180952 | — | — | 1 | 7.75 |
| CHEMBL183565 | — | — | 1 | 7.64 |
| CHEMBL183829 | — | — | 1 | 7.14 |
| CHEMBL360774 | — | — | 1 | 6.94 |
| CHEMBL180819 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182339 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL361162 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL360137 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL183176 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL183050 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL359647 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL183122 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL183000 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL183851 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL182430 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL183863 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL183727 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL183057 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL180952 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL183565 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL183829 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL360774 | — | EC50 | = | 115.0 | nM | 6.94 |
| CHEMBL180819 | — | EC50 | = | 495.0 | nM | 6.30 |