Assay Detail
Binding
CHEMBL829044
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Inhibition of [3H]-8-OH-DPAT binding to human 5-hydroxytryptamine 1B receptor expressed in CHO cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.82 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL606556 | — | — | 1 | 8.37 |
| CHEMBL2113386 | — | — | 1 | 8.03 |
| CHEMBL606547 | — | — | 1 | 7.82 |
| CHEMBL609742 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL606556 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL2113386 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL606547 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL609742 | — | Ki | = | 88.0 | nM | 7.06 |