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Assay Detail

CHEMBL829064

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]-PD 128907 binding to Dopamine receptor D3 in rat ventral striatum
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Ventral striatum
Confidence 9 — Direct single protein target
Curated By Expert

Target

D(3) dopamine receptor (CHEMBL3138)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Enantiomerically pure hexahydropyrazinoquinolines as potent and selective dopamine 3 subtype receptor ligands.
Ding K, Ding K, Chen J, Ji M, Wu X, Varady J, Yang CY, Lu Y, Deschamps JR, Levant B, Wang S.
J Med Chem (2005) 48 : 3171 -3181
PubMed 15857123 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 7.46 8.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL25236 BP-897 1 8.96
CHEMBL426629 1 8.48
CHEMBL192650 1 8.39
CHEMBL524005 1 8.24
CHEMBL434532 1 8.08
CHEMBL371200 1 8.03
CHEMBL191894 1 8.00
CHEMBL427173 1 7.80
CHEMBL179757 1 7.75
CHEMBL191815 1 7.72
CHEMBL363406 1 7.36
CHEMBL192138 1 7.17
CHEMBL192439 1 7.02
CHEMBL193040 1 6.90
CHEMBL341774 1 6.52
CHEMBL190821 1 5.33
CHEMBL193300 1 5.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL25236 BP-897 Ki = 1.1 nM 8.96
CHEMBL426629 Ki = 3.3 nM 8.48
CHEMBL192650 Ki = 4.1 nM 8.39
CHEMBL524005 Ki = 5.7 nM 8.24
CHEMBL434532 Ki = 8.3 nM 8.08
CHEMBL371200 Ki = 9.3 nM 8.03
CHEMBL191894 Ki = 10.0 nM 8.00
CHEMBL427173 Ki = 16.0 nM 7.80
CHEMBL179757 Ki = 18.0 nM 7.75
CHEMBL191815 Ki = 19.0 nM 7.72
CHEMBL363406 Ki = 44.0 nM 7.36
CHEMBL192138 Ki = 67.0 nM 7.17
CHEMBL192439 Ki = 96.0 nM 7.02
CHEMBL193040 Ki = 126.0 nM 6.90
CHEMBL341774 Ki = 304.0 nM 6.52
CHEMBL190821 Ki = 4642.0 nM 5.33
CHEMBL193300 Ki = 7156.0 nM 5.14