Assay Detail
Binding
CHEMBL829085
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In vitro inhibitory concentration against HIV-1 recombinant integrase activity in standard 3'-processing assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: synthesis and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.85 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39092 | — | — | 1 | 5.70 |
| CHEMBL187452 | — | — | 1 | 4.00 |
| CHEMBL188293 | — | — | 1 | - |
| CHEMBL189715 | — | — | 1 | - |
| CHEMBL188712 | — | — | 1 | - |
| CHEMBL189128 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39092 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL187452 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL188293 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL189715 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL188712 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL189128 | — | IC50 | > | 100000.0 | nM | - |