Assay Detail
Binding
CHEMBL829116
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Inhibitory activity against membrane bound tumor associated human carbonic anhydrase IX
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.21 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182455 | — | — | 1 | 8.40 |
| CHEMBL171476 | — | — | 1 | 8.15 |
| CHEMBL183701 | — | — | 1 | 8.02 |
| CHEMBL182440 | — | — | 1 | 8.00 |
| CHEMBL182276 | — | — | 1 | 7.88 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.57 |
| CHEMBL2113026 | — | — | 1 | 7.55 |
| CHEMBL361421 | — | — | 1 | 7.49 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.47 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 7.43 |
| CHEMBL68257 | — | — | 1 | 7.37 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.28 |
| CHEMBL221802 | — | — | 1 | 7.24 |
| CHEMBL360714 | — | — | 1 | 7.21 |
| CHEMBL183240 | — | — | 1 | 7.15 |
| CHEMBL182429 | — | — | 1 | 7.00 |
| CHEMBL181753 | — | — | 1 | 6.28 |
| CHEMBL170139 | — | — | 1 | 5.88 |
| CHEMBL181357 | — | — | 1 | 5.70 |
| CHEMBL353258 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182455 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL171476 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL183701 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL182440 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL182276 | — | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL77517 | INDISULAM | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL2113026 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL361421 | — | Ki | = | 32.1 | nM | 7.49 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL68257 | — | Ki | = | 43.1 | nM | 7.37 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL221802 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL360714 | — | Ki | = | 61.6 | nM | 7.21 |
| CHEMBL183240 | — | Ki | = | 70.8 | nM | 7.15 |
| CHEMBL182429 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL181753 | — | Ki | = | 525.0 | nM | 6.28 |
| CHEMBL170139 | — | Ki | = | 1320.0 | nM | 5.88 |
| CHEMBL181357 | — | Ki | = | 2020.0 | nM | 5.70 |
| CHEMBL353258 | — | Ki | = | 54000.0 | nM | 4.27 |