Assay Detail
Binding
CHEMBL829123
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for kainate Glutamate receptor GluR5 expressed in Sf9 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Glutamate receptor ionotropic, kainate 1 (CHEMBL1918) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.66 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370038 | — | — | 1 | 7.09 |
| CHEMBL276815 | (S)-AMPA | — | 1 | 5.94 |
| CHEMBL370941 | — | — | 1 | 5.54 |
| CHEMBL372643 | — | — | 1 | 5.26 |
| CHEMBL193087 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370038 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL276815 | (S)-AMPA | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL370941 | — | Ki | = | 2920.0 | nM | 5.54 |
| CHEMBL372643 | — | Ki | = | 5450.0 | nM | 5.26 |
| CHEMBL193087 | — | Ki | = | 34200.0 | nM | 4.47 |