Assay Detail
Binding
CHEMBL829148
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Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N- and C-terminal modifications of nociceptin/orphanin FQ generate highly potent NOP receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 9.32 | 10.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414782 | — | — | 1 | 10.12 |
| CHEMBL410653 | — | — | 1 | 9.85 |
| CHEMBL442297 | — | — | 1 | 9.68 |
| CHEMBL264846 | — | — | 1 | 9.51 |
| CHEMBL263588 | — | — | 1 | 9.09 |
| CHEMBL262544 | — | — | 1 | 9.03 |
| CHEMBL396460 | NOCICEPTIN | — | 1 | 8.98 |
| CHEMBL414767 | — | — | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414782 | — | EC50 | = | 0.07586 | nM | 10.12 |
| CHEMBL410653 | — | EC50 | = | 0.1413 | nM | 9.85 |
| CHEMBL442297 | — | EC50 | = | 0.2089 | nM | 9.68 |
| CHEMBL264846 | — | EC50 | = | 0.309 | nM | 9.51 |
| CHEMBL263588 | — | EC50 | = | 0.8128 | nM | 9.09 |
| CHEMBL262544 | — | EC50 | = | 0.9333 | nM | 9.03 |
| CHEMBL396460 | NOCICEPTIN | EC50 | = | 1.047 | nM | 8.98 |
| CHEMBL414767 | — | EC50 | = | 5.248 | nM | 8.28 |