Assay Detail
Functional
CHEMBL829182
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Reduced farnesylation of H-ras transformed NIH3T3 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 1H-pyridin-2-one derivatives as potent and selective farnesyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.17 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128309 | — | — | 1 | 9.30 |
| CHEMBL158553 | — | — | 1 | 8.28 |
| CHEMBL365269 | — | — | 1 | 8.05 |
| CHEMBL363518 | — | — | 1 | 8.00 |
| CHEMBL185492 | — | — | 1 | 7.94 |
| CHEMBL365718 | — | — | 1 | 7.82 |
| CHEMBL183265 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128309 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL158553 | — | EC50 | = | 5.2 | nM | 8.28 |
| CHEMBL365269 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL363518 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL185492 | — | EC50 | = | 11.4 | nM | 7.94 |
| CHEMBL365718 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL183265 | — | EC50 | = | 15.0 | nM | 7.82 |