Assay Detail
Binding
CHEMBL829242
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Inhibitory concentration against Matrix metalloprotease-13 (MMP-13)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.19 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372878 | — | — | 1 | 9.30 |
| CHEMBL191359 | — | — | 1 | 8.92 |
| CHEMBL370312 | — | — | 1 | 8.85 |
| CHEMBL191030 | — | — | 1 | 8.68 |
| CHEMBL192773 | — | — | 1 | 8.55 |
| CHEMBL179552 | — | — | 1 | 8.52 |
| CHEMBL190415 | — | — | 1 | 8.46 |
| CHEMBL189216 | — | — | 1 | 8.37 |
| CHEMBL189052 | — | — | 1 | 8.19 |
| CHEMBL190506 | — | — | 1 | 8.11 |
| CHEMBL372261 | — | — | 1 | 8.10 |
| CHEMBL190563 | — | — | 1 | 7.85 |
| CHEMBL190686 | — | — | 1 | 7.72 |
| CHEMBL189156 | — | — | 1 | 7.44 |
| CHEMBL189975 | — | — | 1 | 7.28 |
| CHEMBL190441 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372878 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL191359 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL370312 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL191030 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL192773 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL179552 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL190415 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL189216 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL189052 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL190506 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL372261 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL190563 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL190686 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL189156 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL189975 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL190441 | — | IC50 | = | 188.0 | nM | 6.73 |