Assay Detail
Binding
CHEMBL829245
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Inhibition of c-Src tyrosine kinase
59
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 59 | 7.06 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL362862 | — | — | 1 | 8.40 |
| CHEMBL181285 | — | — | 1 | 8.40 |
| CHEMBL181423 | — | — | 1 | 8.22 |
| CHEMBL181314 | — | — | 1 | 8.22 |
| CHEMBL49120 | PD-0166285 | 1.0 | 2 | 8.15 |
| CHEMBL179065 | — | — | 1 | 8.15 |
| CHEMBL540206 | — | — | 1 | 8.10 |
| CHEMBL435732 | — | — | 1 | 8.05 |
| CHEMBL181233 | — | — | 1 | 8.05 |
| CHEMBL361347 | — | — | 1 | 7.96 |
| CHEMBL362692 | — | — | 1 | 7.96 |
| CHEMBL180810 | — | — | 1 | 7.92 |
| CHEMBL178758 | — | — | 1 | 7.89 |
| CHEMBL359898 | — | — | 1 | 7.85 |
| CHEMBL369296 | — | — | 1 | 7.85 |
| CHEMBL369732 | — | — | 1 | 7.77 |
| CHEMBL434907 | — | — | 1 | 7.66 |
| CHEMBL181095 | — | — | 1 | 7.64 |
| CHEMBL301612 | — | — | 1 | 7.62 |
| CHEMBL178510 | — | — | 1 | 7.60 |
| CHEMBL180316 | — | — | 1 | 7.55 |
| CHEMBL433559 | — | — | 1 | 7.52 |
| CHEMBL113070 | — | — | 1 | 7.50 |
| CHEMBL180035 | — | — | 1 | 7.41 |
| CHEMBL181733 | — | — | 1 | 7.37 |
| CHEMBL362402 | — | — | 1 | 7.33 |
| CHEMBL180290 | — | — | 1 | 7.30 |
| CHEMBL180149 | — | — | 1 | 7.24 |
| CHEMBL181822 | — | — | 1 | 7.21 |
| CHEMBL425873 | — | — | 1 | 7.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181285 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL362862 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL181314 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL181423 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL179065 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL49120 | PD-0166285 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL540206 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL181233 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL435732 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL361347 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL362692 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL180810 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL178758 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL369296 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL359898 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL369732 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL434907 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL181095 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL301612 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL178510 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL180316 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL433559 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL113070 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL180035 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL181733 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL362402 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL180290 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL180149 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL181822 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL425873 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL179898 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL181476 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL366922 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL178439 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL181282 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL179806 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL360698 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL180448 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL181982 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL360225 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL182044 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL362005 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL180821 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL180401 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL360544 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL180740 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL180673 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL178122 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL360689 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL360672 | — | IC50 | = | 6500.0 | nM | 5.19 |