Assay Detail

CHEMBL829340

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Binding

Inhibitory concentration against CDK4/Cyclin D

ChEMBL ↗

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Target

Cyclin-dependent kinase 4/cyclin D1 (CHEMBL1907601) ↗

Open DB target context

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Cyclin-dependent kinase 4/cyclin D1 (CHEMBL1907601) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cyclin-dependent kinase 4/cyclin D1

CHEMBL1907601

Anchored from Assay target.

Protein identity Cyclin-dependent kinase 4/cyclin D1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	6 — Multiple protein complex / RNA
Curated By	Autocuration

Target

Cyclin-dependent kinase 4/cyclin D1 (CHEMBL1907601) ↗

Type	PROTEIN COMPLEX
Organism	Homo sapiens

Publication

2-Aminoquinazoline inhibitors of cyclin-dependent kinases.

Bathini Y, Singh I, Harvey PJ, Keller PR, Singh R, Micetich RG, Fry DW, Dobrusin EM, Toogood PL.
Bioorg Med Chem Lett (2005) 15 : 3881 -3885
PubMed 15993068 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.70	8.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL359951	—	—	1	8.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL359951	—	IC50	=	2.0	nM	8.70