Assay Detail
Binding
CHEMBL829355
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Concentration required for 50% inhibition of Flap endonuclease-1
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.24 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182748 | — | — | 1 | 6.72 |
| CHEMBL188067 | — | — | 1 | 6.48 |
| CHEMBL183257 | — | — | 1 | 6.39 |
| CHEMBL182756 | — | — | 1 | 6.36 |
| CHEMBL361960 | — | — | 1 | 6.24 |
| CHEMBL185652 | — | — | 1 | 5.87 |
| CHEMBL367585 | — | — | 1 | 5.82 |
| CHEMBL440938 | — | — | 1 | 5.78 |
| CHEMBL185721 | — | — | 1 | 5.76 |
| CHEMBL187154 | — | — | 1 | 5.74 |
| CHEMBL274003 | — | — | 1 | 5.46 |
| CHEMBL363721 | — | — | 1 | 5.46 |
| CHEMBL185787 | — | — | 1 | 5.44 |
| CHEMBL186926 | — | — | 1 | 5.26 |
| CHEMBL184215 | — | — | 1 | 5.16 |
| CHEMBL186181 | — | — | 1 | 5.14 |
| CHEMBL182485 | — | — | 1 | 5.12 |
| CHEMBL183604 | — | — | 1 | 5.00 |
| CHEMBL183027 | — | — | 1 | 4.97 |
| CHEMBL361460 | — | — | 1 | 4.95 |
| CHEMBL185257 | — | — | 1 | 4.91 |
| CHEMBL185898 | — | — | 1 | 4.89 |
| CHEMBL185566 | — | — | 1 | 4.87 |
| CHEMBL364328 | — | — | 1 | 4.84 |
| CHEMBL185879 | — | — | 1 | 4.75 |
| CHEMBL424806 | — | — | 1 | 4.71 |
| CHEMBL19332 | — | — | 1 | 4.60 |
| CHEMBL364984 | — | — | 1 | 4.54 |
| CHEMBL361807 | — | — | 1 | 4.46 |
| CHEMBL185070 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182748 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL188067 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL183257 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL182756 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL361960 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL185652 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL367585 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL440938 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL185721 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL187154 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL274003 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL363721 | — | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL185787 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL186926 | — | IC50 | = | 5530.0 | nM | 5.26 |
| CHEMBL184215 | — | IC50 | = | 6960.0 | nM | 5.16 |
| CHEMBL186181 | — | IC50 | = | 7310.0 | nM | 5.14 |
| CHEMBL182485 | — | IC50 | = | 7650.0 | nM | 5.12 |
| CHEMBL183604 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL183027 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL361460 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL185257 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL185898 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL185566 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL364328 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL185879 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL424806 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL19332 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL364984 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL361807 | — | IC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL185070 | — | IC50 | = | 37900.0 | nM | 4.42 |
| CHEMBL182129 | — | IC50 | = | 46400.0 | nM | 4.33 |
| CHEMBL181810 | — | IC50 | = | 63200.0 | nM | 4.20 |
| CHEMBL177529 | — | IC50 | = | 64200.0 | nM | 4.19 |
| CHEMBL181811 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL361338 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL182290 | — | IC50 | > | 100000.0 | nM | - |