Assay Detail
Binding
CHEMBL829379
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Inhibitory concentration against dipeptidylpeptidase 8 was determined
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 62 | 4.59 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191775 | — | — | 1 | 6.66 |
| CHEMBL22310 | — | — | 1 | 6.00 |
| CHEMBL98408 | — | — | 1 | 5.66 |
| CHEMBL191812 | — | — | 1 | 5.01 |
| CHEMBL364057 | — | — | 1 | 4.77 |
| CHEMBL365780 | — | — | 1 | 4.64 |
| CHEMBL192421 | — | — | 1 | 4.41 |
| CHEMBL195173 | — | — | 1 | 4.38 |
| CHEMBL195905 | — | — | 1 | 4.33 |
| CHEMBL370033 | — | — | 1 | 4.26 |
| CHEMBL195739 | — | — | 1 | 4.24 |
| CHEMBL192449 | — | — | 1 | 4.24 |
| CHEMBL364093 | — | — | 1 | 4.24 |
| CHEMBL192365 | — | — | 1 | 4.21 |
| CHEMBL552788 | — | — | 1 | 4.20 |
| CHEMBL192980 | — | — | 1 | 4.19 |
| CHEMBL195443 | — | — | 1 | 4.13 |
| CHEMBL191514 | — | — | 1 | 4.11 |
| CHEMBL191933 | — | — | 1 | 4.07 |
| CHEMBL189881 | — | — | 1 | 4.06 |
| CHEMBL370072 | — | — | 1 | - |
| CHEMBL192117 | — | — | 1 | - |
| CHEMBL191823 | — | — | 1 | - |
| CHEMBL195667 | — | — | 1 | - |
| CHEMBL191652 | — | — | 1 | - |
| CHEMBL195862 | — | — | 1 | - |
| CHEMBL190979 | — | — | 1 | - |
| CHEMBL370734 | — | — | 1 | - |
| CHEMBL195378 | — | — | 1 | - |
| CHEMBL195755 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191775 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL22310 | — | IC50 | = | 993.0 | nM | 6.00 |
| CHEMBL98408 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL191812 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL364057 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL365780 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL192421 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL195173 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL195905 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL370033 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL195739 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL192449 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL364093 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL192365 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL552788 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL192980 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL195443 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL191514 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL191933 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL189881 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL278729 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL362973 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL363584 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL192983 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL371846 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL365575 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL191354 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL190454 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL194489 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL370079 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL369888 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL365996 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL362930 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL192396 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL191858 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL362976 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL194437 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL191906 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL363175 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL193887 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL195755 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL195378 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL370734 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL190979 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL195862 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL191652 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL195667 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL191823 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL192117 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL370072 | — | IC50 | > | 100000.0 | nM | - |