Assay Detail
Binding
CHEMBL829382
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against human histone deacetylase
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.14 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112234 | — | — | 1 | 7.14 |
| CHEMBL320323 | — | — | 1 | 7.12 |
| CHEMBL112105 | — | — | 1 | 7.10 |
| CHEMBL113421 | — | — | 1 | 7.07 |
| CHEMBL113159 | — | — | 1 | 7.00 |
| CHEMBL332246 | — | — | 1 | 6.96 |
| CHEMBL419758 | — | — | 1 | 6.77 |
| CHEMBL325676 | — | — | 1 | 6.68 |
| CHEMBL322504 | — | — | 1 | 6.68 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.55 |
| CHEMBL178779 | — | — | 1 | 6.47 |
| CHEMBL112211 | — | — | 1 | 6.47 |
| CHEMBL112364 | — | — | 1 | 6.44 |
| CHEMBL109654 | — | — | 1 | 6.43 |
| CHEMBL178727 | — | — | 1 | 6.41 |
| CHEMBL324126 | — | — | 1 | 6.21 |
| CHEMBL112129 | — | — | 1 | 6.21 |
| CHEMBL112311 | — | — | 1 | 5.96 |
| CHEMBL325675 | — | — | 1 | 5.92 |
| CHEMBL326433 | 8-MERCAPTO-OCTANOIC ACID PHENYLAMIDE | — | 1 | 5.82 |
| CHEMBL139192 | — | — | 1 | 5.55 |
| CHEMBL114344 | — | — | 1 | 5.21 |
| CHEMBL111806 | — | — | 1 | 5.15 |
| CHEMBL109796 | — | — | 1 | 4.96 |
| CHEMBL344920 | — | — | 1 | 4.77 |
| CHEMBL178150 | — | — | 1 | 4.66 |
| CHEMBL426239 | — | — | 1 | 4.10 |
| CHEMBL426420 | — | — | 1 | - |
| CHEMBL178542 | — | — | 1 | - |
| CHEMBL111805 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112234 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL320323 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL112105 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL113421 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL113159 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL332246 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL419758 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL325676 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL322504 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL178779 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL112211 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL112364 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL109654 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL178727 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL324126 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL112129 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL112311 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL325675 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL326433 | 8-MERCAPTO-OCTANOIC ACID PHENYLAMIDE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL139192 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL114344 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL111806 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL109796 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL344920 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL178150 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL426239 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL178726 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL178151 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL324053 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL178088 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL112539 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL179202 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL362408 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL111805 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL178542 | — | IC50 | = | 7500000.0 | nM | - |
| CHEMBL426420 | — | IC50 | = | 230000.0 | nM | - |