Assay Detail
Binding
CHEMBL829397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta4
7
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha2/beta4 (CHEMBL2109230) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.15 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405936 | — | — | 2 | 5.64 |
| CHEMBL267936 | MECAMYLAMINE | 4.0 | 2 | 5.51 |
| CHEMBL335712 | — | — | 2 | 5.29 |
| CHEMBL510275 | METHYLLYCACONITINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405936 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL267936 | MECAMYLAMINE | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL405936 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL335712 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL267936 | MECAMYLAMINE | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL335712 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL510275 | METHYLLYCACONITINE | IC50 | > | 1000.0 | nM | - |