Assay Detail
Binding
CHEMBL829399
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Inhibitory concentration against Nicotinic acetylcholine receptor alpha3-beta4
14
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha3/beta4 (CHEMBL1907594) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.05 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412032 | — | — | 1 | 9.52 |
| CHEMBL451252 | — | — | 1 | 7.52 |
| CHEMBL405936 | — | — | 2 | 6.14 |
| CHEMBL267936 | MECAMYLAMINE | 4.0 | 3 | 5.85 |
| CHEMBL894 | BUPROPION | 4.0 | 1 | 5.75 |
| CHEMBL188383 | — | — | 1 | 5.04 |
| CHEMBL335712 | — | — | 2 | 4.37 |
| CHEMBL510275 | METHYLLYCACONITINE | — | 1 | - |
| CHEMBL412033 | — | — | 1 | - |
| CHEMBL265050 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412032 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL451252 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL405936 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL267936 | MECAMYLAMINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL894 | BUPROPION | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL267936 | MECAMYLAMINE | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL267936 | MECAMYLAMINE | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL405936 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL188383 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL335712 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL335712 | — | IC50 | = | 240000.0 | nM | - |
| CHEMBL510275 | METHYLLYCACONITINE | IC50 | > | 1000.0 | nM | - |
| CHEMBL412033 | — | IC50 | > | 750.0 | nM | - |
| CHEMBL265050 | — | IC50 | > | 750.0 | nM | - |