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Assay Detail

CHEMBL829402

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against hepatitis C virus internal ribosomal entry site
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepacivirus hominis
Confidence 3 — Cell-line / Tissue
Curated By Expert

Target

Internal ribosome entry site (IRES) (CHEMBL612412)
Type NUCLEIC-ACID
Organism Hepacivirus hominis

Publication

Control of hepatitis C: a medicinal chemistry perspective.
Gordon CP, Keller PA.
J Med Chem (2005) 48 : 1 -20
PubMed 15633995 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 6.23 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL278037 1 7.70
CHEMBL15583 1 6.00
CHEMBL15754 1 5.66
CHEMBL15727 THIONIN ACETATE 1 5.54
CHEMBL274986 1 -
CHEMBL15137 MICHLER'S KETONE 1 -
CHEMBL273309 1 -
CHEMBL15591 1 -
CHEMBL179214 1 -
CHEMBL275177 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL278037 IC50 = 20.0 nM 7.70
CHEMBL15583 IC50 = 1000.0 nM 6.00
CHEMBL15754 IC50 = 2190.0 nM 5.66
CHEMBL15727 THIONIN ACETATE IC50 = 2860.0 nM 5.54
CHEMBL274986 IC50 > 10000.0 nM -
CHEMBL15137 MICHLER'S KETONE IC50 > 10000.0 nM -
CHEMBL273309 IC50 > 10000.0 nM -
CHEMBL15591 IC50 >> 10000.0 nM -
CHEMBL179214 IC50 >> 10000.0 nM -
CHEMBL275177 IC50 >> 10000.0 nM -