Assay Detail
Binding
CHEMBL829406
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Inhibition of human matrix metalloprotease-3
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.37 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 9.64 |
| CHEMBL514138 | CGS-27023A | — | 1 | 7.66 |
| CHEMBL179288 | — | — | 1 | 7.30 |
| CHEMBL362651 | — | — | 1 | 6.89 |
| CHEMBL181244 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL179288 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL362651 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL181244 | — | IC50 | = | 4500.0 | nM | 5.35 |