Assay Detail
Binding
CHEMBL829419
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Inhibition of [3H]WIN-35428 binding to human dopamine transporter (hDAT)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of 8-thiabicyclo[3.2.1]oct-2-enes and their binding affinity for the dopamine and serotonin transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.34 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186242 | — | — | 1 | 8.35 |
| CHEMBL364146 | — | — | 1 | 8.17 |
| CHEMBL365092 | — | — | 1 | 8.10 |
| CHEMBL187695 | — | — | 1 | 8.04 |
| CHEMBL169429 | — | — | 1 | 7.92 |
| CHEMBL186447 | — | — | 1 | 7.89 |
| CHEMBL185169 | — | — | 1 | 7.70 |
| CHEMBL186488 | — | — | 1 | 7.21 |
| CHEMBL187211 | — | — | 1 | 7.17 |
| CHEMBL363510 | — | — | 1 | 6.66 |
| CHEMBL185792 | — | — | 1 | 6.62 |
| CHEMBL186501 | — | — | 1 | 6.04 |
| CHEMBL361493 | — | — | 1 | 5.56 |
| CHEMBL184867 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186242 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL364146 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL365092 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL187695 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL169429 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL186447 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL185169 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL186488 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL187211 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL363510 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL185792 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL186501 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL361493 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL184867 | — | IC50 | > | 10000.0 | nM | - |