Assay Detail
Binding
CHEMBL829449
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Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.77 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL180650 | — | — | 1 | 8.52 |
| CHEMBL180617 | — | — | 1 | 8.40 |
| CHEMBL369525 | — | — | 1 | 8.30 |
| CHEMBL368241 | — | — | 1 | 8.22 |
| CHEMBL182032 | — | — | 1 | 8.15 |
| CHEMBL362836 | — | — | 1 | 8.10 |
| CHEMBL181728 | — | — | 1 | 7.92 |
| CHEMBL362242 | — | — | 1 | 7.80 |
| CHEMBL362675 | — | — | 1 | 7.66 |
| CHEMBL183596 | — | — | 1 | 7.51 |
| CHEMBL181792 | — | — | 1 | 7.50 |
| CHEMBL183878 | — | — | 1 | 7.48 |
| CHEMBL180846 | — | — | 1 | 6.80 |
| CHEMBL181236 | — | — | 1 | 6.60 |
| CHEMBL426054 | — | — | 1 | 6.58 |
| CHEMBL360742 | — | — | 1 | 6.54 |
| CHEMBL182092 | — | — | 1 | 6.48 |
| CHEMBL181836 | — | — | 1 | 6.22 |
| CHEMBL182153 | — | — | 1 | 6.19 |
| CHEMBL360114 | — | — | 1 | 6.05 |
| CHEMBL367817 | — | — | 1 | 5.96 |
| CHEMBL29097 | — | — | 1 | 5.80 |
| CHEMBL362223 | — | — | 1 | 5.58 |
| CHEMBL555147 | — | — | 1 | 5.50 |
| CHEMBL362663 | — | — | 1 | 5.50 |
| CHEMBL180718 | — | — | 1 | 5.37 |
| CHEMBL178390 | — | — | 1 | 5.19 |
| CHEMBL181986 | — | — | 1 | 5.17 |
| CHEMBL178207 | — | — | 1 | 5.14 |
| CHEMBL180919 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL180650 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL180617 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL369525 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL368241 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL182032 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL362836 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL181728 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL362242 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL362675 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL183596 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL181792 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL183878 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL180846 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL181236 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL426054 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL360742 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL182092 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL181836 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL182153 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL360114 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL367817 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL29097 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL362223 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL555147 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL362663 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL180718 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL178390 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL181986 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL178207 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL180919 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL181390 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL179026 | — | IC50 | > | 10000.0 | nM | - |