Assay Detail
Functional
CHEMBL829460
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In vitro antiplasmodial concentration against multidrug-resistant Plasmodium falciparum K1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.50 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192343 | — | — | 1 | 7.31 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | 6.75 |
| CHEMBL191734 | — | — | 1 | 6.02 |
| CHEMBL92023 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192343 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL191734 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL92023 | — | IC50 | = | 1210.0 | nM | 5.92 |