Assay Detail
Binding
CHEMBL829484
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against human poly (ADP-ribose) polymerase 1 (PARP-1)
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Phthalazinones. Part 1: The design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.44 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370838 | — | — | 1 | 8.42 |
| CHEMBL370217 | — | — | 1 | 8.39 |
| CHEMBL436298 | — | — | 1 | 8.30 |
| CHEMBL196444 | — | — | 1 | 8.30 |
| CHEMBL196450 | — | — | 1 | 8.17 |
| CHEMBL195966 | — | — | 1 | 8.02 |
| CHEMBL197192 | — | — | 1 | 8.01 |
| CHEMBL382950 | — | — | 1 | 8.00 |
| CHEMBL195402 | — | — | 1 | 7.92 |
| CHEMBL195464 | — | — | 1 | 7.89 |
| CHEMBL363617 | — | — | 1 | 7.89 |
| CHEMBL195913 | — | — | 1 | 7.72 |
| CHEMBL371425 | — | — | 1 | 7.70 |
| CHEMBL383578 | — | — | 1 | 7.57 |
| CHEMBL371205 | — | — | 1 | 7.48 |
| CHEMBL371244 | — | — | 1 | 7.44 |
| CHEMBL193903 | — | — | 1 | 7.33 |
| CHEMBL381208 | — | — | 1 | 7.30 |
| CHEMBL196507 | — | — | 1 | 7.26 |
| CHEMBL372450 | — | — | 1 | 7.25 |
| CHEMBL425560 | — | — | 1 | 7.05 |
| CHEMBL381652 | — | — | 1 | 7.05 |
| CHEMBL193638 | — | — | 1 | 6.94 |
| CHEMBL196559 | — | — | 1 | 6.92 |
| CHEMBL370692 | — | — | 1 | 6.75 |
| CHEMBL193918 | — | — | 1 | 6.72 |
| CHEMBL193917 | — | — | 1 | 6.54 |
| CHEMBL193512 | — | — | 1 | 6.43 |
| CHEMBL196883 | — | — | 1 | 6.27 |
| CHEMBL66761 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370838 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL370217 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL436298 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL196444 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL196450 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL195966 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL197192 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL382950 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL195402 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL195464 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL363617 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL195913 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL371425 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL383578 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL371205 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL371244 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL193903 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL381208 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL196507 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL372450 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL425560 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL381652 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL193638 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL196559 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL370692 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL193918 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL193917 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL193512 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL196883 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL66761 | — | IC50 | = | 770.0 | nM | 6.11 |