Assay Detail
Binding
CHEMBL829503
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of bovine smooth muscle phosphodiesterase 4
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Muscle tissue |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design of small-sized libraries by combinatorial assembly of linkers and functional groups to a given scaffold: application to the structure-based optimization of a phosphodiesterase 4 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.65 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL195155 | — | — | 1 | 9.05 |
| CHEMBL363562 | — | — | 1 | 7.70 |
| CHEMBL195446 | — | — | 1 | 7.70 |
| CHEMBL365177 | — | — | 1 | 7.22 |
| CHEMBL434354 | — | — | 1 | 7.10 |
| CHEMBL313842 | ZARDAVERINE | 2.0 | 1 | 6.10 |
| CHEMBL372055 | — | — | 1 | 5.70 |
| CHEMBL192124 | — | — | 1 | 5.10 |
| CHEMBL192779 | — | — | 1 | 4.22 |
| CHEMBL194551 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL195155 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL363562 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL195446 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL365177 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL434354 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL313842 | ZARDAVERINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL372055 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL192124 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL192779 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL194551 | — | IC50 | > | 10000.0 | nM | - |