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Assay Detail

CHEMBL829529

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Binding
Inhibitory concentration against HIV-1 integrase mediated 3' processing reaction
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Confidence 9 — Direct single protein target
Curated By Expert

Target

Human immunodeficiency virus type 1 integrase (CHEMBL3471)
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors.
Sechi M, Derudas M, Dallocchio R, Dessì A, Bacchi A, Sannia L, Carta F, Palomba M, Ragab O, Chan C, Shoemaker R, Sei S, Dayam R, Neamati N.
J Med Chem (2004) 47 : 5298 -5310
PubMed 15456274 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.32 4.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL189718 1 4.96
CHEMBL186820 1 4.92
CHEMBL188302 1 4.80
CHEMBL363333 1 4.70
CHEMBL188145 1 4.46
CHEMBL361659 1 4.35
CHEMBL365421 1 4.30
CHEMBL183469 1 4.26
CHEMBL187971 1 4.07
CHEMBL186055 1 4.03
CHEMBL188631 1 4.00
CHEMBL186914 1 4.00
CHEMBL442414 1 4.00
CHEMBL188686 1 4.00
CHEMBL187821 1 4.00
CHEMBL188190 1 -
CHEMBL187970 1 -
CHEMBL364097 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL189718 IC50 = 11000.0 nM 4.96
CHEMBL186820 IC50 = 12000.0 nM 4.92
CHEMBL188302 IC50 = 16000.0 nM 4.80
CHEMBL363333 IC50 = 20000.0 nM 4.70
CHEMBL188145 IC50 = 35000.0 nM 4.46
CHEMBL361659 IC50 = 45000.0 nM 4.35
CHEMBL365421 IC50 = 50000.0 nM 4.30
CHEMBL183469 IC50 = 55000.0 nM 4.26
CHEMBL187971 IC50 = 85000.0 nM 4.07
CHEMBL186055 IC50 = 93000.0 nM 4.03
CHEMBL188631 IC50 = 100000.0 nM 4.00
CHEMBL186914 IC50 = 100000.0 nM 4.00
CHEMBL442414 IC50 = 100000.0 nM 4.00
CHEMBL188686 IC50 = 100000.0 nM 4.00
CHEMBL187821 IC50 = 100000.0 nM 4.00
CHEMBL188190 IC50 > 100000.0 nM -
CHEMBL187970 IC50 - nM -
CHEMBL364097 IC50 > 100000.0 nM -