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Assay Detail

CHEMBL829533

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of trypsin like activity of the proteasome in colon carcinoma cell lines COO115
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 2 — Organism
Curated By Expert

Target

Proteasome (CHEMBL612443)
Type SUBCELLULAR

Publication

Peptidyl vinyl ester derivatives: new class of selective inhibitors of proteasome trypsin-like activity.
Marastoni M, Baldisserotto A, Cellini S, Gavioli R, Tomatis R.
J Med Chem (2005) 48 : 5038 -5042
PubMed 16033282 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.39 7.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL189919 1 7.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL189919 IC50 = 41.0 nM 7.39