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Assay Detail

CHEMBL829547

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards human 5-hydroxytryptamine 1B receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 1B (CHEMBL1898)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands.
Prisinzano T, Dukat M, Law H, Slassi A, MacLean N, DeLannoy I, Glennon RA.
Bioorg Med Chem Lett (2004) 14 : 4697 -4699
PubMed 15324890 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 6.15 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL366322 1 7.92
CHEMBL312448 XYLOMETAZOLINE 3.0 1 7.89
CHEMBL182837 1 5.84
CHEMBL307408 1 5.80
CHEMBL361729 1 5.73
CHEMBL360803 PI-CLONIDINE 1 5.70
CHEMBL361470 1 5.35
CHEMBL183704 1 4.99
CHEMBL770 TOLAZOLINE 4.0 1 -
CHEMBL71033 1 -
CHEMBL186961 1 -
CHEMBL186919 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL366322 Ki = 12.0 nM 7.92
CHEMBL312448 XYLOMETAZOLINE Ki = 13.0 nM 7.89
CHEMBL182837 Ki = 1430.0 nM 5.84
CHEMBL307408 Ki = 1570.0 nM 5.80
CHEMBL361729 Ki = 1862.0 nM 5.73
CHEMBL360803 PI-CLONIDINE Ki = 1980.0 nM 5.70
CHEMBL361470 Ki = 4435.0 nM 5.35
CHEMBL183704 Ki = 10240.0 nM 4.99
CHEMBL770 TOLAZOLINE Ki > 10000.0 nM -
CHEMBL71033 Ki > 10000.0 nM -
CHEMBL186961 Ki > 30000.0 nM -
CHEMBL186919 Ki > 30000.0 nM -