Assay Detail
Binding
CHEMBL829549
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Binding affinity for Dopamine receptor D4
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.72 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 9.48 |
| CHEMBL141845 | — | — | 1 | 9.17 |
| CHEMBL310843 | — | — | 1 | 8.66 |
| CHEMBL7927 | FAUC 113 | — | 1 | 8.44 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.14 |
| CHEMBL124444 | — | — | 1 | 7.52 |
| CHEMBL59725 | — | — | 1 | 6.47 |
| CHEMBL88937 | — | — | 1 | 5.89 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL141845 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL310843 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL7927 | FAUC 113 | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL124444 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL59725 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL88937 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL26 | SULPIRIDE | Ki | = | 2100.0 | nM | 5.68 |